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Vol.026 // Wed 07.01.26LIVE42.6°N · reading time varies
LeadGLP-1 · Peptides · Health · Fitness

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HEAVY HITTERS.

GLP-1s: what we actually know after two years of useGLP-1
8 min·May 22, 2026·Dr. Rowan Vela

GLP-1s: what we actually know after two years of use

Semaglutide and tirzepatide reshaped weight-loss conversations overnight. Here is what the long-tail data is starting to say.

Overheard

"GLP-1s didn't make me disciplined — they made discipline possible."

— reader, 34, week 22
The recovery stack: BPC-157, TB-500 and the case for patience
Peptides

The recovery stack: BPC-157, TB-500 and the case for patience

The Feed

POSTED TODAY.

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Sunrise, seven days in on my mini-cut. Peptides help but discipline still wins.
@quietstrength
Sunrise, seven days in on my mini-cut. Peptides help but discipline still wins.
40g protein overnight oats — the exact recipe that keeps me full on 0.5mg.
@rd.samantha
40g protein overnight oats — the exact recipe that keeps me full on 0.5mg.
Zone 2 in the forest before it gets hot. 45min, HR 138.▶ Reel
@trail.iris
Zone 2 in the forest before it gets hot. 45min, HR 138.
Week 12 journal. Down 18lb, sleeping through the night, running further than I did at 25.
@journaled
Week 12 journal. Down 18lb, sleeping through the night, running further than I did at 25.
Two kettlebell sessions a week are non-negotiable for me. Lean mass is the whole game.
@lift.slow
Two kettlebell sessions a week are non-negotiable for me. Lean mass is the whole game.
Latest drops

RECENT NOTES.

Zone 2 cardio on appetite-suppressing peptides#01
Fitness · 4 min

Zone 2 cardio on appetite-suppressing peptides

Training aerobic base while eating in a deep deficit takes a small adjustment. Here's the framework.

PT-141 and the neurochemistry of desire#02
Peptides · 7 min

PT-141 and the neurochemistry of desire

A melanocortin agonist that acts on the brain rather than the vasculature — what the research actually shows.

Sleep is the peptide multiplier you're ignoring#03
Science · 5 min

Sleep is the peptide multiplier you're ignoring

Growth hormone, ghrelin, leptin — all of them read your sleep debt before they read your protocol.

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